"We have at last made a connection between Wnt signaling and human hair disease that is highly significant," said Dr. Christiano. "We have years of beautiful data in our field about hair growth in mice, but this is the first inroad into showing that the same pathway is critical in human hair growth. This is the first mutation in a Wnt inhibitor that deregulates the pathway in a human hair disease."

"Furthermore, these findings suggest that manipulating the Wnt pathway may have an effect on hair follicle growth - for the first time, in humans," said Dr. Christiano. "And unlike commonly available treatments for hair loss that involve blocking hormonal pathways, treatments involving the Wnt pathway would be non-hormonal, which may enable many more people suffering from hair loss to receive such therapies."

Dr. Christiano and her team are now working to understand the complex genetic causes of other forms of hair loss including alopecia areata, with the hope of eventually developing new, effective treatments for these conditions.

SOURCE Columbia University Medical Center

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