Working with molecular microbiologist Gilmore are: David Hooper, MD (Associate Chief of Infectious Diseases and Head of Infection Control, MGH and Professor of Medicine, HMS); Suzanne Walker, Ph.D. (Professor of Microbiology and Molecular Genetics, HMS); Eleftherios Mylonakis, MD, PhD (Assistant Professor of Medicine, HMS and Member, Infectious Diseases, MGH); and Frederick M. Ausubel, Ph.D., Professor of Genetics HMS, and Member, Molecular Biology, MGH).

Walker, Mylonakis and Ausubel will be taking different high-throughput approaches to screen libraries of compounds for possible new drugs. Gilmore, Hooper and Mylonakis will then test these compounds for their ability to clear an infection, and will also examine possible pathways for the development of resistance. These projects will additionally benefit from input from, Richard Losick, Ph.D. (Harvard College Professor and Maria Moors Cabot Professor of Biology), who will assist Gilmore on his subproject, as well as head an advisory panel.

Other world leaders in the area of antibiotic resistance who will be members of the advisory panel are Christopher T. Walsh, Ph.D., (Hamilton Kuhn Professor of Biological Chemistry and Molecular Pharmacology, HMS); Jared Silverman, Ph.D. (Senior Director, In Vitro Biology, Cubist Pharmaceuticals, Inc.), and Steven J. Projan, Ph.D (Vice President and Global Head, Infectious Diseases, Novartis Pharmaceuticals, Inc.). "The involvement of thought leaders from the pharmaceutical industry will be an important key to the ultimate translation of the results of this project," according to Gilmore.

Source: Schepens Eye Research Institute